What is a Troche?troche example from PCCA

A troche is subbuccal lozenge that is taken orally and allowed to dissolve under the tongue, supposedly to allow greater absorption without consequence of the 'first-pass' metabolism suffered by medications taken otherwise orally. Additional benefit includes that medication administed under the tongue minimises exposure of the medication to the differing pH environment of the stomach and upper gastrointestinal tract.

There are two different types of troches; soft gelatin style troches and hard polyglycol style troches. We note that the hard polyglycol style troches allow for easier dosage and easier preparation in a more stable form with flavouring, excipients and longevity of the item for postage/storage and handling.

Essentially they are prepared into molds as noted on the right which provide 30 dosage troches. Each troche may then be quartered if necessary, providing an accurate dosage form for subbuccal administration. Each individual troche is approximately 10mm x 10mm.

Items that are commonly prepared into troche form include:

  • Vitamin B12 (hydroxocoblamin / cyanocoblamin / methylcobalamin)¬†
  • BHRT including progesterone, estrogen (combinations of the individual estrogens; estrone, estradiol, estriol - sometimes known as Bi-Est or Tri-Est), DHEA, testosterone,¬†pregnenolone
  • Human chorionic gonadotropin¬†(hCG)
  • sildenafil
  • promethazine

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